Use of the painDETECT tool in rheumatoid arthritis suggests neuropathic and sensitization components in pain reporting.

Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted toward synovial joints. Inhibition of proinflammatory networks by disease-modifying antirheumatic drugs, eg, methotrexate and biologic therapies, including tumor necrosis factor-α inhibitors, often leads to suppression of disease activity observed at the clinical level. However, despite the era of widespread use of disease-modifying treatments, there remain significant groups of patients who continue to experience pain. Our study formulated a pain assessment tool in the arthritis clinic to assess feasibility of measurements including the visual analog scale (VAS) and painDETECT to assess multimodal features of pain in people with established RA (n=100). Clinical measures of disease activity (Disease Activity Score in 28 Joints [DAS28]) were also recorded. Our data showed that despite the majority of subjects on at least one disease-modifying agent, the majority of patients reported severe pain (54%) by VAS, despite well-controlled clinical disease, with mean DAS28 2.07±0.9. Using the painDETECT questionnaire, 67% of patients had unlikely neuropathic pain. A significant proportion of subjects (28%) had possible neuropathic pain and 5% had features of likely neuropathic pain by painDETECT scoring. We found a positive correlation between VAS and painDETECT (R (2)=0.757). Of note, the group who had likely or probable neuropathic pain also showed significantly increased pain reporting by VAS (P30) also had statistically higher proportions of pain reporting (VAS 89.0±0.7 mm) compared with subjects who had a normal body mass index (VAS 45.2±21.8 mm), P<0.05. Our findings suggest that multimodal features of pain perception exist in RA, including neuropathic and sensitization elements, perhaps explaining why a subgroup of people with RA continue to experience ongoing pain, despite their apparent suppression of inflammation

Dark Matter implications of Fermi-LAT measurement of anisotropies in the diffuse gamma-ray background

The detailed origin of the diffuse gamma-ray background is still unknown. However, the contribution of unresolved sources is expected to induce small-scale anisotropies in this emission, which may provide a way to identify and constrain the properties of its contributors. Recent studies have predicted the contributions to the angular power spectrum (APS) from extragalactic and galactic dark matter (DM) annihilation or decay. The Fermi-LAT collaboration reported detection of angular power with a significance larger than $3\sigma$ in the energy range from 1 GeV to 10 GeV on 22 months of data [Ackermann et al. 2012]. For these preliminary results the already published Fermi-LAT APS measurements [Ackermann et al. 2012] are compared to the accurate predictions for DM anisotropies from state-of-the-art cosmological simulations as presented in [Fornasa et al. 2013] to derive constraints on different DM candidates.Comment: 2012 Fermi Symposium proceedings - eConf C12102

Multiwavelength study of the starburst galaxy NGC7714. I: Ultraviolet-Optical spectroscopy

We have studied the physical conditions in the central 300 pc of the proto-typical starburst galaxy NGC 7714. Our analysis is based on ultraviolet spectroscopy with the HST+GHRS and ground-based optical observations.The data are interpreted using evolutionary models optimized for young starburst regions. The massive stellar population is derived in a self-consistent way using the continuum and stellar absorption lines in the ultraviolet and the nebular emission line optical spectrum. The central starburst has an age of about 4.5 Myr, with little evidence for an age spread. Wolf-Rayet features at the ultraviolet indicates a stellar population of $\sim$ 2000 Wolf-Rayet stars. The overall properties of the newly formed stars are quite similar to those derived, e.g., in 30 Doradus. A standard Salpeter IMF is consistent with all observational constraints. We find evidence for spatial structure within the central 300 pc sampled. Therefore it is unlikely that the nucleus of NGC 7714 hosts a single star cluster exceeding the properties of other known clusters. Contrary to previous suggestions, we find no evidence for a nuclear supernova rate that would significantly exceed the total disk-integrated rate. About one supernova event per century is predicted.Comment: 19 pages, 9 figures in a tar file. Accepted for publication in ApJ, 1999, March, issue 51

Inter-band B(E2) transition strengths in odd-mass heavy deformed nuclei

Inter-band B(E2) transition strengths between different normal parity bands in 163Dy and 165Er are described using the pseudo-SU(3) model. The Hamiltonian includes Nilsson single-particle energies, quadrupole-quadrupole and pairing interactions with fixed, parametrized strengths, and three extra rotor terms used to fine tune the energy spectra. In addition to inter-band transitions, the energy spectra and the ground state intra-band B(E2) strengths are reported. The results show the pseudo-SU(3) shell model to be a powerful microscopic theory for a description of the normal parity sector in heavy deformed odd-A nuclei.Comment: 4 figures, 2 table

Avaliação de pesticidas e coliformes fecais em águas subterrâneas sobre influência de sistemas agrossilvipastoris.

Resumo

Adubação nitrogenada na soja?.

Adubacao nitrogenada da soja; Inoculacao da soja.bitstream/item/53933/1/57.pd

El rol del control personal en la función paliativa de la justificación del sistema entre la población indígena y no indígena de estudiantes peruanos

Indexación: Scopus.In this article we propose a mediation model for the association between system justification and psychological well-being (i.e., the palliative function of ideology), based on system justification theory and compensatory control theory. Specifically, we argue that endorsing system-justifying beliefs leads to increased perceived personal control, which in turn predicts higher well-being. We used a convenience sample of students from two Peruvian universities. The results showed that system justification was related to general psychological well-being and personal control. In addition, indigenous students rated lower on system justification, general psychological well-being, self-esteem and personal control. Next, we found that the association between system justification and general psychological well-being was stronger among indigenous students, and this relationship was partially mediated by personal control. In addition, we showed that the mediation model is moderated by ethnicity, so that personal control is a mediator only among non-indigenous participants. We conclude that personal control is a mechanism involved in the palliative function of ideology among this group. Finally, we discuss possible explanations for the mechanisms involved in the palliative function of ideology among low-status individuals. © 2018, © 2018 Fundacion Infancia y Aprendizaje.En este artículo se propone un modelo de mediación de las relaciones entre la justificación del sistema y el bienestar psicológico (i.e., la función paliativa de la ideología) basado en las teorías de la justificación del sistema y del control compensatorio. En concreto, se propone que la adopción de creencias justificativas del sistema produce un aumento del control personal percibido que, a su vez, predice niveles más elevados de bienestar. En este estudio se utilizó una muestra por conveniencia de estudiantes provenientes de dos universidades peruanas. Los resultados muestran que la justificación del sistema está relacionada con el bienestar psicológico general y con el control personal. Además, los estudiantes indígenas mostraron niveles más reducidos de justificación del sistema, bienestar psicológico general, autoestima y control personal. También se observó que la relación entre la justificación del sistema y el bienestar psicológico general era más fuerte entre los estudiantes indígenas y que el control personal mediaba parcialmente en esta relación. Asimismo, mostramos que la etnicidad es un factor moderador del modelo de mediación, por lo que el control personal es un mediador únicamente entre los participantes no indígenas. El estudio concluye que el control personal es un mecanismo que interviene en la función paliativa de la ideología en este grupo. Por último, se discuten posibles explicaciones de los mecanismos implicados en la función paliativa de la ideología entre individuos de estatus social bajo.https://www.tandfonline.com/doi/full/10.1080/02134748.2018.153765